Titre | Robust helix formation in a new family of oligoureas based on a constrained bicyclic building block. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Legrand, B, André, C, Wenger, E, Didierjean, C, Averlant-Petit, MChristine, Martinez, J, Calmes, M, Amblard, M |
Journal | Angew Chem Int Ed Engl |
Volume | 51 |
Issue | 45 |
Pagination | 11267-70 |
Date Published | 2012 Nov 5 |
ISSN | 1521-3773 |
Mots-clés | Bicyclo Compounds, Circular Dichroism, Models, Molecular, Molecular Conformation, Nuclear Magnetic Resonance, Biomolecular, Octanes, Protein Structure, Secondary, Urea |
Abstract | BAC for more: a constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution and in the solid state. A robust H-bond (dotted line) network was found between the carbonyl oxygen atoms (red) and the amino groups (dark blue) within the helix. |
DOI | 10.1002/anie.201205842 |
Alternate Journal | Angew. Chem. Int. Ed. Engl. |
PubMed ID | 23038643 |