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Robust helix formation in a new family of oligoureas based on a constrained bicyclic building block.

TitreRobust helix formation in a new family of oligoureas based on a constrained bicyclic building block.
Publication TypeJournal Article
Year of Publication2012
AuthorsLegrand, B, André, C, Wenger, E, Didierjean, C, Averlant-Petit, MChristine, Martinez, J, Calmes, M, Amblard, M
JournalAngew Chem Int Ed Engl
Volume51
Issue45
Pagination11267-70
Date Published2012 Nov 5
ISSN1521-3773
Mots-clésBicyclo Compounds, Circular Dichroism, Models, Molecular, Molecular Conformation, Nuclear Magnetic Resonance, Biomolecular, Octanes, Protein Structure, Secondary, Urea
Abstract

BAC for more: a constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution and in the solid state. A robust H-bond (dotted line) network was found between the carbonyl oxygen atoms (red) and the amino groups (dark blue) within the helix.

DOI10.1002/anie.201205842
Alternate JournalAngew. Chem. Int. Ed. Engl.
PubMed ID23038643