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Biodegradable nanoparticles made from polylactide-grafted dextran copolymers.

TitreBiodegradable nanoparticles made from polylactide-grafted dextran copolymers.
Publication TypeJournal Article
Year of Publication2009
AuthorsNouvel, C, Raynaud, J, Marie, E, Dellacherie, E, Six, J-L, Durand, A
JournalJ Colloid Interface Sci
Volume330
Issue2
Pagination337-43
Date Published2009 Feb 15
ISSN1095-7103
Mots-clésCoated Materials, Biocompatible, Dextranase, Dextrans, Excipients, Hydrolysis, Materials Testing, Nanoparticles, Polyesters
Abstract

Polysaccharide-covered polyester nanoparticles were prepared using the emulsion/solvent evaporation process. The core of the nanoparticles was made either of PLA or of a blend of polylactide and polylactide-grafted dextran copolymer in various proportions. The surface of the nanoparticles was covered by dextran chains via the use of water-soluble polylactide-grafted dextrans as polymeric stabilizers during the emulsification step. The characteristics of the nanoparticles (size, surface coverage, thickness of superficial layer, colloidal stability) were correlated to the structural parameters (length and number of polylactide grafts) of the copolymers as well as to their surface active properties. The complete biodegradability of the nanoparticles was evaluated by considering the rate of hydrolysis of polylactide grafts in phosphate buffer and the rate of enzymatic degradation of dextran backbone by dextranase.

DOI10.1016/j.jcis.2008.10.069
Alternate JournalJ Colloid Interface Sci
PubMed ID19022457