Titre | Biodegradable nanoparticles made from polylactide-grafted dextran copolymers. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Nouvel, C, Raynaud, J, Marie, E, Dellacherie, E, Six, J-L, Durand, A |
Journal | J Colloid Interface Sci |
Volume | 330 |
Issue | 2 |
Pagination | 337-43 |
Date Published | 2009 Feb 15 |
ISSN | 1095-7103 |
Mots-clés | Coated Materials, Biocompatible, Dextranase, Dextrans, Excipients, Hydrolysis, Materials Testing, Nanoparticles, Polyesters |
Abstract | Polysaccharide-covered polyester nanoparticles were prepared using the emulsion/solvent evaporation process. The core of the nanoparticles was made either of PLA or of a blend of polylactide and polylactide-grafted dextran copolymer in various proportions. The surface of the nanoparticles was covered by dextran chains via the use of water-soluble polylactide-grafted dextrans as polymeric stabilizers during the emulsification step. The characteristics of the nanoparticles (size, surface coverage, thickness of superficial layer, colloidal stability) were correlated to the structural parameters (length and number of polylactide grafts) of the copolymers as well as to their surface active properties. The complete biodegradability of the nanoparticles was evaluated by considering the rate of hydrolysis of polylactide grafts in phosphate buffer and the rate of enzymatic degradation of dextran backbone by dextranase. |
DOI | 10.1016/j.jcis.2008.10.069 |
Alternate Journal | J Colloid Interface Sci |
PubMed ID | 19022457 |